pentobarbital will decrease the extent or effect of netupitant/palonosetron by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Netupitant is mainly metabolized by CYP3A4; stay clear of use in patients who're chronically applying a powerful CYP3A4 inducerIt is best to see your Health care provider as en